Immunological aspects of experimental pneumoconiosis. Final report
Technical Report
·
OSTI ID:5599726
The purpose of the study was to ascertain what the immunologic responses were of animals as a result of chronic exposure to coal dusts over extended periods of time and to determine what effect the lung reactive antibodies have on the pathogenesis of experimental pneumoconiosis. A group of 200 male CFN-rats was exposed to coal dust aerosols. No evidence of serologic findings appeared until after 9 months of coal mine dust exposure, indicating that a long standing chronic exposure was needed to initiate measurable antilung activity. The authors concluded the rat was a poor animal for the study of any form of pulmonary diseases due to the prevalence of mycoplasma infections; that the mouse appeared to be a better animal for the microbiological and immunological study; that both rats and mice appeared to show the same immunologic abnormalities as humans upon long standing exposure; that the demonstration of cell mediated immunity to a homologous lung antigen in coal mine dust exposed rats was a discovery of fundamental importance; and that the role of secondary infections in coal workers pneumoconiosis should receive further study.
- Research Organization:
- Health Services and Mental Health Administration, Rockville, MD (United States)
- OSTI ID:
- 5599726
- Report Number(s):
- PB-91-173435/XAB; HSM--099-71-0022
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
01 COAL, LIGNITE, AND PEAT
016000* -- Coal
Lignite
& Peat-- Health & Safety
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
ANTIBODIES
ANTIGENS
BIOLOGICAL EFFECTS
BODY
CHRONIC EXPOSURE
COAL FINES
COAL MINERS
COAL MINING
COLLOIDS
DISEASES
DISPERSIONS
IMMUNOLOGY
LUNGS
MAMMALS
MICE
MINERS
MINING
OCCUPATIONAL EXPOSURE
ORGANS
PATHOLOGY
PERSONNEL
PNEUMOCONIOSES
RATS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SOLS
VERTEBRATES
016000* -- Coal
Lignite
& Peat-- Health & Safety
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
ANTIBODIES
ANTIGENS
BIOLOGICAL EFFECTS
BODY
CHRONIC EXPOSURE
COAL FINES
COAL MINERS
COAL MINING
COLLOIDS
DISEASES
DISPERSIONS
IMMUNOLOGY
LUNGS
MAMMALS
MICE
MINERS
MINING
OCCUPATIONAL EXPOSURE
ORGANS
PATHOLOGY
PERSONNEL
PNEUMOCONIOSES
RATS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SOLS
VERTEBRATES