Microfabricated chemical separation and analysis devices
- Oak Ridge National Lab., TN (United States)
Microfabricated devices that perform chemical analysis procedures have primarily focused on chemical separation methods. The first such device was a gas chromatograph fabricated on a silicon wafer, reported over a decade ago. This seminal work did not produce significant interest from the chemical measurements community due to low performance characteristics. More recently there has been renewed microfabricated chemical instruments but with a focus on electrophoresis devices and analysis of fluids in general. In moving to the liquid state and employing electrokinetic transport phenomena, microfabricated chemical analysis devices have delivered performance features equivalent to or exceeding that of conventional laboratory instrumentation. Furthermore, these new devices show promise for integration of multiple laboratory functions that accomplish a complete assay, i.e., placing the features of an entire laboratory on a chip. Ultimately one would like to have a collection of micro-laboratory components (the analogues of resistors, transistors, etc.) that could be designed into new devices to solve specific measurement problems. Realization of these micro-laboratory components could allow a paradigm shift for chemical and biochemical synthesis and analysis similar to that provided to electronics by the transistor and integrated circuit. Some of the components we have developed for the laboratory on a chip will be described. The use of these components in integrated devices that perform automated chemical kinetics experiments and DNA restriction fragment analyses at the subnanoliter scale will be presented.
- OSTI ID:
- 559864
- Report Number(s):
- CONF-970443--
- Country of Publication:
- United States
- Language:
- English
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