Rat renal mesenchymal tumor as an experimental model for human congenital mesoblastic nephroma: I. Induction

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Pediatr. Pathol.; (United States)

DOI:https://doi.org/10.3109/15513818909022341· OSTI ID:5595504

Hasgekar, N N; Pendse, A M; Lalitha, V S

The effect of low-dose (2 Gy) radiation on ethylnitrosourea (ENU)-induced neoplasms was studied in Sprague-Dawley and Holtzman strains of rats. With a 60 mg/kg dose of ENU administered on day 1 in Sprague-Dawley rats, 18.4% of the neoplasms induced were found in the kidney. When the same dose of ENU was given on day 10, the incidence of kidney tumors fell to 2.8%. Prior (2 Gy) radiation on day 9 enhanced kidney tumor induction to 16.1%, a trend also observed in the case of ENU-induced neural tumors. In Holtzman rats, 40 mg/kg ENU induced more kidney tumors (12.5%) when given on day 4 than on day 0, and prior irradiation enhanced the ENU-induced kidney tumors even though the interval between irradiation and carcinogen administration was fairly long--4 days.

• Research Organization: Cancer Research Institute, Parel, Bombay (India)
• OSTI ID: 5595504
• Journal Information: Pediatr. Pathol.; (United States), Vol. 9:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
KIDNEYS
NEOPLASMS
RADIOINDUCTION
NITROSOUREAS
CARCINOGENESIS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
COBALT ISOTOPES
EXPERIMENTAL NEOPLASMS
GENETIC VARIABILITY
LOW DOSE IRRADIATION
RADIATION DOSES
RATS
SYNERGISM
TOXICITY
WHOLE-BODY IRRADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL VARIABILITY
BODY
DISEASES
DOSES
EXTERNAL IRRADIATION
IRRADIATION
ISOTOPES
MAMMALS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
560152 - Radiation Effects on Animals- Animals