Rat renal mesenchymal tumor as an experimental model for human congenital mesoblastic nephroma: I. Induction

Journal Article · Sat Dec 31 23:00:00 EST 1988 · Pediatr. Pathol.; (United States)

DOI:https://doi.org/10.3109/15513818909022341· OSTI ID:5595504

Hasgekar, N N; Pendse, A M; Lalitha, V S

The effect of low-dose (2 Gy) radiation on ethylnitrosourea (ENU)-induced neoplasms was studied in Sprague-Dawley and Holtzman strains of rats. With a 60 mg/kg dose of ENU administered on day 1 in Sprague-Dawley rats, 18.4% of the neoplasms induced were found in the kidney. When the same dose of ENU was given on day 10, the incidence of kidney tumors fell to 2.8%. Prior (2 Gy) radiation on day 9 enhanced kidney tumor induction to 16.1%, a trend also observed in the case of ENU-induced neural tumors. In Holtzman rats, 40 mg/kg ENU induced more kidney tumors (12.5%) when given on day 4 than on day 0, and prior irradiation enhanced the ENU-induced kidney tumors even though the interval between irradiation and carcinogen administration was fairly long--4 days.

• Research Organization: Cancer Research Institute, Parel, Bombay (India)
• OSTI ID: 5595504
• Journal Information: Pediatr. Pathol.; (United States), Journal Name: Pediatr. Pathol.; (United States) Vol. 9:2; ISSN PPATD
• Country of Publication: United States
• Language: English

Related Subjects

560152 -- Radiation Effects on Animals-- Animals
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL VARIABILITY
BODY
CARCINOGENESIS
COBALT ISOTOPES
DISEASES
DOSES
EXPERIMENTAL NEOPLASMS
EXTERNAL IRRADIATION
GENETIC VARIABILITY
IRRADIATION
ISOTOPES
KIDNEYS
LOW DOSE IRRADIATION
MAMMALS
NEOPLASMS
NITROSO COMPOUNDS
NITROSOUREAS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RATS
RODENTS
SYNERGISM
TOXICITY
VERTEBRATES
WHOLE-BODY IRRADIATION