Uptake of carbon-11-methionine and fluorodeoxyglucose in non-Hodgkin's lymphoma: A PET study

Journal Article · Sat Jun 01 00:00:00 EDT 1991 · Journal of Nuclear Medicine; (United States)

OSTI ID:5594459

Leskinen-Kallio, S; Ruotsalainen, U; Nagren, K T; Teraes, M J; Joensuu, H ^[1]

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1. Department of Oncology and Radiotherapy, Turku University Central Hospital (Finland)

Uptake of L-(methyl-11C)methionine (11C-methionine) and (18F)-2-fluoro-2-deoxy-D-glucose (FDG) was studied with PET in 14 patients with non-Hodgkin's lymphomas. The low molecular weight fraction of venous plasma separated by fast gel filtration was used as the input function for 11C-methionine studies, and tracer accumulation was analyzed according to Patlak and Gjedde. The average uptake rate of 11C-methionine was 0.0775 {plus minus} 0.0245 min-1 (s.d.) and of FDG 0.0355 {plus minus} 0.0293 min-1, 11C-methionine uptake rate being significantly higher than that of FDG (p less than 0.01). Carbon-11-methionine accumulated strongly in all but one of the lymphomas. FDG accumulated clearly in lymphomas of high-grade malignancy, whereas two intermediate- and three low-grade malignant lymphomas had a poor uptake rate. The tumor/plasma ratio of both 11C-methionine and FDG increased faster in high and intermediate-grade lymphomas than in low-grade lymphomas, but there was considerable overlap between the histologic grades. Carbon-11-methionine seems to be preferable in detecting tumors, while FDG was superior to 11C-methionine in distinguishing the high-grade malignant lymphomas from the other grades.

• OSTI ID: 5594459
• Journal Information: Journal of Nuclear Medicine; (United States), Journal Name: Journal of Nuclear Medicine; (United States) Vol. 32:6; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
DIAGNOSIS
DISEASES
DRUGS
EVEN-ODD NUCLEI
FILTRATION
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
IMMUNE SYSTEM DISEASES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIPOTROPIC FACTORS
LYMPHOMAS
METHIONINE
MINUTES LIVING RADIOISOTOPES
MOLECULAR WEIGHT
MONOSACCHARIDES
NANOSEC LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PATIENTS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SACCHARIDES
SEPARATION PROCESSES
UPTAKE