Altered metabolic incorporation of fucose and leucine into PNS myelin of 25-week-old diabetic (C57BL/Ks (db/db)) mice: effects of untreated diabetes on nerve metabolism
Journal Article
·
· Neurochem. Res.; (United States)
Sciatic nerves of 25-week-old genetically diabetic (C57BL/Ks (db/db)) mice and their litter-mate controls were removed, and their metabolic incorporation of (/sup 3/H)fucose and (/sup 14/C)leucine into myelin was studied in vitro. Untreated diabetic animals showed significant increases (p less than 0.05) in the fucose/leucine incorporation into myelin when compared to values found for their litter-mates. These results correlated well with previous experiments performed on alloxan or streptozotocin-diabetic rats and thus show the in vitro incubation procedure to be a good indicator of altered metabolic conditions in peripheral nerves due to diabetes mellitus. The resulting ratio increases seen in diabetic animals is at variance with the decrease in ratios found in animals undergoing typical Wallerian degeneration. These results suggest that different metabolic processes operate in untreated diabetics than in normals or in those undergoing other degenerative nerve processes.
- Research Organization:
- Department of Anatomy, Indiana University School of Medicine, Indianapolis
- OSTI ID:
- 5590285
- Journal Information:
- Neurochem. Res.; (United States), Journal Name: Neurochem. Res.; (United States) Vol. 8:4; ISSN NERED
- Country of Publication:
- United States
- Language:
- English
Similar Records
Incorporation of fucose and leucine into PNS myelin proteins in nerves undergoing early Wallerian degeneration
Synthesis of myelin, particulate, and soluble protein subfractions of rat sciatic nerve during the early stage of Wallerian degeneration: a comparison of metabolic studies using double and single isotope methods and recovery
Peripheral nerve metabolism and zinc levels in streptozotocin induced diabetic rats. Effect of diets high in fish and corn oil
Journal Article
·
Sat Jan 31 23:00:00 EST 1981
· Neurochem. Res.; (United States)
·
OSTI ID:5405793
Synthesis of myelin, particulate, and soluble protein subfractions of rat sciatic nerve during the early stage of Wallerian degeneration: a comparison of metabolic studies using double and single isotope methods and recovery
Journal Article
·
Thu Dec 31 23:00:00 EST 1981
· Neurochem. Res.; (United States)
·
OSTI ID:6933397
Peripheral nerve metabolism and zinc levels in streptozotocin induced diabetic rats. Effect of diets high in fish and corn oil
Conference
·
Thu Mar 14 23:00:00 EST 1991
· FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
·
OSTI ID:5239718
Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
BIOLOGICAL MODELS
BIOSYNTHESIS
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
DIABETES MELLITUS
DISEASES
DOUBLE LABELLING
ENDOCRINE DISEASES
HEXOSES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LABELLING
LEUCINE
LIPIDS
LIPOPROTEINS
MAMMALS
METABOLIC DISEASES
METABOLISM
MICE
MONOSACCHARIDES
MYELIN
NERVES
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PROTEINS
RODENTS
SACCHARIDES
SCIATIC NERVE
SYNTHESIS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
BIOLOGICAL MODELS
BIOSYNTHESIS
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
DIABETES MELLITUS
DISEASES
DOUBLE LABELLING
ENDOCRINE DISEASES
HEXOSES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LABELLING
LEUCINE
LIPIDS
LIPOPROTEINS
MAMMALS
METABOLIC DISEASES
METABOLISM
MICE
MONOSACCHARIDES
MYELIN
NERVES
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PROTEINS
RODENTS
SACCHARIDES
SCIATIC NERVE
SYNTHESIS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES