Infra-red technique for cerebral blood flow: comparison with /sup 133/Xenon clearance
A rapid infra-red optical technique has been developed for the measurement of cerebral blood flow. The method measures optical density changes across the intact skull during the passage of a bolus of the dye. Cardio-Green (CG). The clearance curves obtained for CG boluses are very short (less than 30 sec) in comparison with those obtained with tracers such as /sup 133/Xenon (10-30 min) that distribute into cerebral tissue. The volume of distribution of CG is totally intravascular, and the dye is relatively slowly cleared from the body. The important advantages of this spectrophotometric technique are its speed, versatility, and the avoidance of radioactive materials. The differential spectrophotometer used in this study, with trivial modifications, has been used to monitor changes in brain blood volume, oxygen saturation of hemoglobin, and cortical mitochondrial respiratory function, which illustrate the versatility of the technique for neurological assessments.
- OSTI ID:
- 5586941
- Journal Information:
- Neurol. Res.; (United States), Vol. 3:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BLOOD FLOW
MEASURING METHODS
NEAR INFRARED RADIATION
DIAGNOSTIC USES
XENON 133
BRAIN
COMPARATIVE EVALUATIONS
DUCKS
DYES
OPACITY
OXYGEN
QUANTITY RATIO
RADIONUCLIDE KINETICS
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIRDS
BODY
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
ELECTROMAGNETIC RADIATION
ELEMENTS
EVEN-ODD NUCLEI
FOWL
INFRARED RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NERVOUS SYSTEM
NONMETALS
NUCLEI
OPTICAL PROPERTIES
ORGANS
PHYSICAL PROPERTIES
RADIATIONS
RADIOISOTOPES
USES
VERTEBRATES
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques