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T suppressor cells are required for the maintenance of the antigen-induced B-cell unresponsive state in humans

Journal Article · · J. Clin. Immunol.; (United States)
DOI:https://doi.org/10.1007/BF00915488· OSTI ID:5586867
;
Tetanus toxoid immunization of humans generates circulating B cells which secrete IgG anti-tetanus toxoid antibodies (IgG-Tet) when stimulated in vitro with T cells and pokeweed mitogen (PWM). A unique property of these cells is the inhibition of maturation into antibody-secreting plasma cells following a 1-hr in vitro pulse with tetanus toxoid. Studies were undertaken to determine if different T-cell subsets could modulate the in vitro generated B-cell unresponsive state. The addition of OKT4+/OKT8- cells to antigen-treated B cells resulted in a partial reversal of the antigen-induced inhibition of IgG-Tet synthesis. The addition of OKT4-/OKT8+ cells to the treated B cells caused a suppression of IgG-Tet synthesis comparable to that seen in cultures containing unfractionated T cells. These results indicate that (1) the B-cell unresponsive state generated by antigen treatment is not absolute, (2) the degree of B-cell unresponsiveness results from a balance of suppressor and helper signals, and (3) T-suppressor cells need to be present to induce and maintain the B-cell unresponsive state.
Research Organization:
Department of Microbiology and Immunology, University of California, Los Angeles, School of Medicine
OSTI ID:
5586867
Journal Information:
J. Clin. Immunol.; (United States), Journal Name: J. Clin. Immunol.; (United States) Vol. 3:2; ISSN JCIMD
Country of Publication:
United States
Language:
English

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Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANTIBODIES
ANTIGENS
BACTERIAL DISEASES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
IMMUNE REACTIONS
IMMUNITY
INFECTIOUS DISEASES
INOCULATION
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MONOCLONAL ANTIBODIES
SOMATIC CELLS
TETANUS
TOXIC MATERIALS
TOXINS
VACCINES