Hypertrophic cardiomyopathy in infants: clinical features and natural history

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.65.1.7· OSTI ID:5586614

Maron, B J ^[1]; Tajik, A J; Ruttenberg, H D; Graham, T P; Atwood, G F; Victorica, B E; Lie, J T; Roberts, W C

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1. National Inst. of Health, Bethesda, MD

The clinical and morphologic features of hypertrophic cardiomyopathy in 20 patients recognized as having cardiac disease in the first year of life are described. Fourteen of these 20 infants were initially suspected of having heart disease solely because a heart murmur was identified. However, the infants showed a variety of clinical findings, including signs of marked congestive heart failure (in the presence of nondilated ventricular cavities and normal or increased left ventricular contractility) and substantial cardiac enlargement on chest radiograph. Other findings were markedly different from those usually present in older children and adults with hypertrophic cardiomyopathy (e.g., right ventricular hypertrophy on the ECG and cyanosis). Consequently, in 14 infants, the initial clinical diagnosis was congenital cardiac malformation other than hypertrophic cardiomyopathy. The clinical course was variable in these patients, but the onset of marked congestive heart failure in the first year of life appeared to be an unfavorable prognostic sign; nine of the 11 infants with congestive heart failure died within the first year of life. In infants with hypertrophic cardiomyopathy, unlike older children and adults with this condition, sudden death was less common (two patients) than death due to progressive congestive heart failure.

• OSTI ID: 5586614
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 65:1; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
BIOMEDICAL RADIOGRAPHY
CARDIOVASCULAR DISEASES
CHILDREN
COMPARATIVE EVALUATIONS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
INFANTS
MEDICINE
NUCLEAR MEDICINE
PATIENTS
RADIOLOGY
ULTRASONOGRAPHY