Loss of vascular fibrinolytic activity following irradiation of the liver--an aspect of late radiation damage

Journal Article · Thu Sep 01 00:00:00 EDT 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576107· OSTI ID:5585850

Henderson, B W; Bicher, H I; Johnson, R J

The vascular fibrinolytic activity, known to originate from the endothelium, was studied histochemically by fibrinolysis autography in liver samples from beagles exposed to radiation treatment. Eighteen to thirty months prior to sacrifice, six dogs received X irradiation (4600 rad in 5 weeks) and three dogs received X irradiation plus aspirin (1 g/kg). Two dogs served as untreated controls. Control livers showed extensive fibrinolytic activity related to large and small vascular structures. The vascular fibrinolytic activity had been lost from all vessels except the major portal branches in five irradiated livers and was severely diminished in three. One irradiated liver appeared to possess normal fibrinolytic activity.

• Research Organization: Department of Radiation Medicine, Roswell Park Memorial Institute, Buffalo, New York
• OSTI ID: 5585850
• Journal Information: Radiat. Res.; (United States), Vol. 95:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LIVER
DELAYED RADIATION EFFECTS
ACETYLSALICYLIC ACID
BEAGLES
FEMALES
FIBRINOLYSIS
X RADIATION
ANALGESICS
ANIMALS
ANTIPYRETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMICAL REACTIONS
DECOMPOSITION
DIGESTIVE SYSTEM
DOGS
DRUGS
ELECTROMAGNETIC RADIATION
GLANDS
HYDROXY ACIDS
IONIZING RADIATIONS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROTEOLYSIS
RADIATION EFFECTS
RADIATIONS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals