Loss of vascular fibrinolytic activity following irradiation of the liver - an aspect of late radiation damage
The vascular fibrinolytic activity, known to originate from the endothelium, was studied histochemically by fibrinolysis autography in liver samples from beagles exposed to radiation treatment. Eighteen to thirty months prior to sacrifice, six dogs received x irradiation (4600 rad in 5 weeks) and three dogs received x irradiation plus aspirin (1 g/kg). Two dogs served as untreated controls. Control livers showed extensive fibrinolytic activity related to large and small vascular structures. The vascular fibrinolytic activity had been lost from all vessels except the major portal branches in five irradiated livers and was severaly diminished in three. One irradiated liver appeared to possess normal fibrinolytic activity.
- Research Organization:
- Roswell Park Memorial Inst., Buffalo, NY
- OSTI ID:
- 5427581
- Journal Information:
- Radiat. Res.; (United States), Vol. 95:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
FIBROSIS
RADIOINDUCTION
LIVER
DELAYED RADIATION EFFECTS
FIBRINOLYSIS
ACETYLSALICYLIC ACID
AUTORADIOGRAPHY
BEAGLES
COBALT 60
GAMMA RADIATION
X RADIATION
ANALGESICS
ANIMALS
ANTIPYRETICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMICAL REACTIONS
COBALT ISOTOPES
DECOMPOSITION
DIGESTIVE SYSTEM
DOGS
DRUGS
ELECTROMAGNETIC RADIATION
GLANDS
HYDROXY ACIDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEOLYSIS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
550900 - Pathology