Induced recovery from near- and far-UV damage in cultured marsupial cells
Thesis/Dissertation
·
OSTI ID:5585630
Colony-forming ability of cultured rat kangaroo cells (Ptk-2) decreases with increasing exposure to light from a daylight fluorescent lamp. After reaching a minimum, survival increases with further exposure, forming a V-shaped survival curve. This increase is inhibited by low concentrations of the protein synthesis inhibitor cycloheximide. The resulting V-shaped survival curve was characterized with respect to several experimental parameters; it appears to be due to an induced repair system dependent on protein synthesis. These results suggest that induced repair, dependent on protein synthesis, in response to fluorescent, near UV, and far UV light damage, is a major repair pathway in Ptk-2 cells, and provides a characterizable system that can elucidate induced repair mechanisms in other mammalian cells.
- Research Organization:
- Texas Univ., Dallas (USA)
- OSTI ID:
- 5585630
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOSYNTHESIS
CELL CULTURES
ELECTROMAGNETIC RADIATION
FAR ULTRAVIOLET RADIATION
MAMMALS
MARSUPIALS
NEAR ULTRAVIOLET RADIATION
ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SURVIVAL CURVES
SYNTHESIS
ULTRAVIOLET RADIATION
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOSYNTHESIS
CELL CULTURES
ELECTROMAGNETIC RADIATION
FAR ULTRAVIOLET RADIATION
MAMMALS
MARSUPIALS
NEAR ULTRAVIOLET RADIATION
ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SURVIVAL CURVES
SYNTHESIS
ULTRAVIOLET RADIATION
VERTEBRATES