Effects of microwave exposure on the hamster immune system. II. Peritoneal macrophage function

Journal Article · Sat Jan 01 00:00:00 EST 1983 · Bioelectromagnetics (N.Y.); (United States)

OSTI ID:5584232

Rama Rao, G; Cain, C A; Lockwood, J; Tompkins, W A

Acute exposure to hamsters to microwave energy (2.45 GHz; 25 mW/cm2 for 60 min) resulted in activation of peritoneal macrophages that were significantly more viricidal to vaccinia virus as compared to sham-exposed or normal (minimum-handling) controls. Macrophages from microwave-exposed hamsters became activated as early as 6 h after exposure and remained activated for up to 12 days. The activation of macrophages by microwave exposure paralleled the macrophage activation after vaccinia virus immunization. Activated macrophages from vaccinia-immunized hamsters did not differ in their viricidal activity when the hamsters were microwave- or sham-exposed. Exposure for 60 min at 15 mW/cm2 did not activate the macrophages while 40 mW/cm2 exposure was harmful to some hamsters. Average maximum core temperatures in the exposed (25 mW/cm2) and sham groups were 40.5 degrees C (+/- 0.35 SD) and 38.4 degrees C (+/- 0.5 SD), respectively. In vitro heating of macrophages to 40.5 degrees C was not as effective as in vivo microwave exposure in activating macrophages to the viricidal state. Macrophages from normal, sham-exposed, and microwave-exposed hamsters were not morphologically different, and they all phagocytosed India ink particles. Moreover, immune macrophage cytotoxicity for virus-infected or noninfected target cells was not suppressed in the microwave-irradiated group (25 mW/cm2, 1 h) as compared to sham-exposed controls, indicating that peritoneal macrophages were not functionally suppressed or injured by microwave hyperthermia.

• Research Organization: Radiation Oncology Training Program, University of Illinois, Urbana-Champaign
• OSTI ID: 5584232
• Journal Information: Bioelectromagnetics (N.Y.); (United States), Vol. 4:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MICROWAVE RADIATION
IMMUNOSUPPRESSION
HAMSTERS
HYPERTHERMIA
MACROPHAGES
ANIMAL CELLS
ANIMALS
BODY TEMPERATURE
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
MAMMALS
PHAGOCYTES
RADIATIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
560400* - Other Environmental Pollutant Effects