The effect of age on blood flow in the proximal femur in man

Journal Article · Sun Nov 01 04:00:00 EST 1981 · J. Nucl. Med.; (United States)

OSTI ID:5583967

Lahtinen, T; Alhava, E M; Karjalainen, P; Romppanen, T

blood flow in the proximal femur was measured in 45 healthy male and female adults by means of a Xe-133 washout method. On the basis of a two-compartment exponential model, blood flow was calculated assuming that the compartments were hematopoietic (red) marrow and nonhematopoietic tissues of bone. Between the ages of 20 and 55 the bone perfusion was 8.3 +/- 1.4 (1 s.d.) ml/100 g/min, decreasing thereafter in older patients. During the same period the red-marrow blood flow (RMBF) decreased linearly: RMBF (ml/100 g/min) . -0.14 x age + 24.5. The nonhematopoietic bone perfusion changed like the bone perfusion. The fractional masses of red marrow and nonhematopoietic tissues of bone in the greater trochanteric region of the femur were determined morphometrically from the bone biopsies of seven adult cadavers. They agreed with the values estimated by the Xe-133 washout method. The blood-flow values will be used as reference values for the Xe-133 bone circulation method.

• Research Organization: Kuopio University Central Hospital, Finland
• OSTI ID: 5583967
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:11; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
BLOOD FLOW
BODY
BONE MARROW
COMPARTMENTS
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
FEMUR
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ORGANS
PATIENTS
PERFUSED TISSUES
PHYSIOLOGY
RADIOISOTOPES
SKELETON
TISSUES
XENON 133
XENON ISOTOPES