Effect of estradiol and hydrocortisone on the process of peroxidation of mitochondrial membrane lipids in irradiated rat liver. [/sup 60/Co. gamma. rays]
Experiments were conducted on male, mongrel albino rats. They were exposed to /sup 60/Co ..gamma.. radiation once, in a dosage of 600 R. Estradiol and hydrocortisone were given intraperitoneally at the rate of 1 mg/kg, 2 h before irradiation or 2, 24 and 72 h after exposure. The animals were sacrificed 5 days after irradiation. These studies established that single exposure of animals to radiation in a dosage of 600 R leads to activation of processes of peroxidation of membrane lipids of the hepatic mitochondria. When estradiol is given 2 and 4 days before sacrificing, one observes acceleration of processes of peroxidation of lipids without reliable change in malonic dialdehyde content. Administration of estrogen 5 days prior to sacrificing leads to a drop of malonic dialdehyde level, which is indicative of attenuation of the process of lipid peroxidation. Administration of hydrocortisone is associated with elevation of the latency period and level of peroxidation after 5 days, as compared to intact animals. Injection of this hormone 2 days before sacrificing the animals leads to attenuation and decrease in rate of peroxidation. The obtained data indicate that there are different mechanisms involved in the inhibitory effects of estradiol and hydrocortisone on peroxidation of lipids of mitochondrial membranes of the rat liver, activated by irradiation. Thus, it may be assumed that steroid hormones are actively involved in regulation of lipid peroxidation when mammals are exposed to radiation. (ERB)
- Research Organization:
- Second Moscow State Medical Inst., USSR
- OSTI ID:
- 5577631
- Journal Information:
- Radiobiology (USSR) (Engl. Transl.); (United States), Vol. 18:2; Other Information: Translated from Radiobiologiya; 18: No. 2, 262-265(1978)
- Country of Publication:
- United States
- Language:
- English
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CELL MEMBRANES
BIOLOGICAL RADIATION EFFECTS
ESTRADIOL
RADIOSENSITIVITY EFFECTS
HYDROCORTISONE
LIPIDS
OXIDATION
RADIOINDUCTION
ACUTE IRRADIATION
BIOCHEMICAL REACTION KINETICS
COBALT 60
COMPARATIVE EVALUATIONS
EXPERIMENTAL DATA
GAMMA RADIATION
INTRAPERITONEAL INJECTION
ISOLATED VALUES
LETHAL IRRADIATION
LIVER
MITOCHONDRIA
RATS
WHOLE-BODY IRRADIATION
ACUTE EXPOSURE
ADRENAL HORMONES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CHEMICAL REACTIONS
COBALT ISOTOPES
CORTICOSTEROIDS
DATA
DATA FORMS
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
ESTRANES
ESTROGENS
EXTERNAL IRRADIATION
GLANDS
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
KINETICS
MAMMALS
MEMBRANES
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PREGNANES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
REACTION KINETICS
RODENTS
STEROID HORMONES
STEROIDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
560114 - Radiation Effects on Biochemicals- In Animals- (-1987)