Reproductive toxicity of 2,4-toluenediamine in the rat. 1. Effect on male fertility

Journal Article · Tue Jan 01 04:00:00 EST 1985 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398509530786· OSTI ID:5575097

Thysen, B; Varma, S K; Bloch, E

Effects of 2,4-toluenediamine (TDA) on reproduction in adult male Sprague-Dawley rats were evaluated. Diets containing 0, 0.01 and 0.03% TDA were fed ad libitum to experimental animals for 10 wk. No signs of toxicity were found. Exposure to the high dose resulted in decreased mating frequency and an increase in infertile matings. Light-microscopic examination of the testes revealed reduced numbers of sperm in the seminiferous tubules and cauda epididymides. These results indicate that TDA is capable of reducing fertility and of exerting an inhibitory or toxic effect on spermatogenesis in the rat.

• Research Organization: Yeshiva Univ., Bronx, NY
• OSTI ID: 5575097
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 16:6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BODY
CHELATING AGENTS
DOSE-RESPONSE RELATIONSHIPS
FERTILITY
GAMETOGENESIS
GONADS
INGESTION
INHIBITION
INTAKE
MALE GENITALS
MALES
MAMMALS
ORGANIC COMPOUNDS
ORGANS
RATS
REPRODUCTION
RODENTS
SPERMATOGENESIS
TDA
TESTES
TOXICITY
VERTEBRATES