Reproductive toxicity screen of 1,3,5-trinitrobenzene administered in the diet of sprague-dawley rats. Final report, September 1993-June 1994
Several Army installations targeted for restoration have measurable quantities of 1,3,5-trinitrobenzene (TNB) in the soil and ground water. As part of the process to develop environmental and health effects criteria for restoration, a modified Screening Information Data Set (SIDS) reproductive study was performed. Male and female Sprague-Dawley rats received diet containing approximately 300, 150, or 30 mg Th%B/kg diet. Mating occurred following 14 days of treatment. All dams, one-half the males, and representative pups were maintained for a total of 90 days of treatment. No mortality occurred during the study; however, a decrease in mean body weights was noted in both sexes of high-dose rats. A dose-related effect was noted in measurements of sperm function/activity. Sperm depletion and degeneration of the seminiferous tubules were noted histopathologically. Methemoglobinemia and splenic hemosiderosis were common findings in the high- and mid-dose levels of both sexes at necropsy. No adverse effects were noted in mating or fertility indices. No significant treatment-related differences were found in length of gestation, sex ratio, gestation index, or mean number of pups per litter.
- Research Organization:
- ManTech Environmental Technology, Inc., Dayton, OH (United States)
- OSTI ID:
- 189813
- Report Number(s):
- AD-A-298912/7/XAB; CNN: Contract F33615-90-C-0532; TRN: 60360687
- Resource Relation:
- Other Information: PBD: Oct 1994
- Country of Publication:
- United States
- Language:
- English
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