Interaction of selenium with cadmium and mercury in semen and reproductive tissues: in vivo and in vitro studies
Studies were conducted to investigate the metabolism of selenium (Se), and the influences of Se on the metabolism of cadmium (Cd) and inorganic mercury (Hg) in rats, and in ram semen in vitro. Se-deficient (-Se) or Se-adequate (+Se) rats were injected intraperitoneally with either /sup 109/CdCl/sub 2/ or /sup 203/HgNO/sub 3/. Semen ejaculates from yearling Suffolk rams were used for the in vitro studies. Whole-body retention of Cd and Hg in rats was significantly increased by Se. However, regardless of the Se status, the predominant route of Cd and Hg excretion was feces. Data on whole tissue Cd retention for both -Se and +Se rats gave the following order of decreasing tissue Cd levels: liver > kidney > testis > epididymis > seminal vesicles > prostate > brain. Cd and Hg concentrations ranging from 10/sup -6/ to 10/sup -2/ M were shown to be injurious to ram sperm in vitro as indicated by the depressed motility and reduced oxygen uptake.
- Research Organization:
- Oregon State Univ., Corvallis (USA)
- OSTI ID:
- 5574724
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CADMIUM 109
TISSUE DISTRIBUTION
UPTAKE
CADMIUM CHLORIDES
MERCURY 203
MERCURY NITRATES
SELENIUM COMPOUNDS
SPERMATOZOA
BIOLOGICAL FUNCTIONS
IN VITRO
IN VIVO
METABOLISM
REPRODUCTION
RETENTION
SHEEP
TOXICITY
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM ISOTOPES
CHLORIDES
CHLORINE COMPOUNDS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
GAMETES
GERM CELLS
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MERCURY COMPOUNDS
MERCURY ISOTOPES
NITRATES
NITROGEN COMPOUNDS
NUCLEI
OXYGEN COMPOUNDS
RADIOISOTOPES
RUMINANTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
550501 - Metabolism- Tracer Techniques