Early indicators of male reproductive toxicity

Journal Article · Tue Mar 01 04:00:00 EST 1988 · Risk Anal.; (United States)

DOI:https://doi.org/10.1111/j.1539-6924.1988.tb01150.x· OSTI ID:6970756

Overstreet, J W; Samuels, S J; Day, P; Hendrickx, A G; Prahalada, S; Mast, T; Katz, D F; Sakai, C

Longitudinal data were analyzed for seminal characteristics of rhesus monkeys and beagles. The monkeys were exposed to DBCP; the beagles were exposed to acute or chronic whole body gamma irradiation. The semen was analyzed for volume and sperm concentration. Sperm were measured for percent motility, swimming speed, and head dimensions. Abnormalities of the sperm tail were also noted. All treatments resulted in measurable effects on the semen parameters. Sperm production, as evaluated by seminal sperm concentration or total sperm numbers in the ejaculate, was as informative of testicular toxicity as any other parameter or combination of parameters. A consistent finding was that changes in sperm output occurred concomitantly with changes in sperm motility.

• Research Organization: Univ. of California, Davis (USA)
• OSTI ID: 6970756
• Journal Information: Risk Anal.; (United States), Journal Name: Risk Anal.; (United States) Vol. 8:1; ISSN RIAND
• Country of Publication: United States
• Language: English

Related Subjects

560152 -- Radiation Effects on Animals-- Animals
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ALKANES
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHRONIC EXPOSURE
CHRONIC IRRADIATION
DOGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMETES
GAMMA RADIATION
GERM CELLS
HYDROCARBONS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MONKEYS
ORGANIC COMPOUNDS
PRIMATES
PROPANE
RADIATION EFFECTS
RADIATIONS
REPRODUCTION
SPERMATOZOA
TOXICITY
VERTEBRATES
WHOLE-BODY IRRADIATION