Interaction of selenium with cadmium and mercury in semen and reproductive tissues: in vivo and in vitro studies
Thesis/Dissertation
·
OSTI ID:5574724
Studies were conducted to investigate the metabolism of selenium (Se), and the influences of Se on the metabolism of cadmium (Cd) and inorganic mercury (Hg) in rats, and in ram semen in vitro. Se-deficient (-Se) or Se-adequate (+Se) rats were injected intraperitoneally with either /sup 109/CdCl/sub 2/ or /sup 203/HgNO/sub 3/. Semen ejaculates from yearling Suffolk rams were used for the in vitro studies. Whole-body retention of Cd and Hg in rats was significantly increased by Se. However, regardless of the Se status, the predominant route of Cd and Hg excretion was feces. Data on whole tissue Cd retention for both -Se and +Se rats gave the following order of decreasing tissue Cd levels: liver > kidney > testis > epididymis > seminal vesicles > prostate > brain. Cd and Hg concentrations ranging from 10/sup -6/ to 10/sup -2/ M were shown to be injurious to ram sperm in vitro as indicated by the depressed motility and reduced oxygen uptake.
- Research Organization:
- Oregon State Univ., Corvallis (USA)
- OSTI ID:
- 5574724
- Country of Publication:
- United States
- Language:
- English
Similar Records
Early indicators of male reproductive toxicity
Whole body retention and tissue distribution of (/sup 203/Hg)methylmercury in adult cats
Use of new field methods of semen analysis in the study of occupational hazards to reproduction: the example of ethylene dibromide
Journal Article
·
Mon Feb 29 23:00:00 EST 1988
· Risk Anal.; (United States)
·
OSTI ID:6970756
Whole body retention and tissue distribution of (/sup 203/Hg)methylmercury in adult cats
Journal Article
·
Tue Dec 31 23:00:00 EST 1974
· Toxicol. Appl. Pharmacol.; (United States)
·
OSTI ID:7265320
Use of new field methods of semen analysis in the study of occupational hazards to reproduction: the example of ethylene dibromide
Journal Article
·
Mon Nov 30 23:00:00 EST 1987
· JOM, J. Occup. Med.; (United States)
·
OSTI ID:5348068
Related Subjects
550501 -- Metabolism-- Tracer Techniques
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
CADMIUM 109
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM ISOTOPES
CHLORIDES
CHLORINE COMPOUNDS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
GAMETES
GERM CELLS
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
IN VITRO
IN VIVO
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MERCURY 203
MERCURY COMPOUNDS
MERCURY ISOTOPES
MERCURY NITRATES
METABOLISM
NITRATES
NITROGEN COMPOUNDS
NUCLEI
OXYGEN COMPOUNDS
RADIOISOTOPES
REPRODUCTION
RETENTION
RUMINANTS
SELENIUM COMPOUNDS
SHEEP
SPERMATOZOA
TISSUE DISTRIBUTION
TOXICITY
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
CADMIUM 109
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM ISOTOPES
CHLORIDES
CHLORINE COMPOUNDS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
GAMETES
GERM CELLS
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
IN VITRO
IN VIVO
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MERCURY 203
MERCURY COMPOUNDS
MERCURY ISOTOPES
MERCURY NITRATES
METABOLISM
NITRATES
NITROGEN COMPOUNDS
NUCLEI
OXYGEN COMPOUNDS
RADIOISOTOPES
REPRODUCTION
RETENTION
RUMINANTS
SELENIUM COMPOUNDS
SHEEP
SPERMATOZOA
TISSUE DISTRIBUTION
TOXICITY
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES