Nephrotoxic and hepatotoxic effects of chromium compounds in rats

Journal Article · Sat Mar 01 04:00:00 EST 1986 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01623516· OSTI ID:5573598

Laborda, R; Diaz-Mayans, J; Nunez, A

The nephrotoxic, hepatotoxic and cardiotoxic actions of hexavalent chromium compounds, as well as their effects on lung, blood and circulation may contribute to the fatal outcome of chromium intoxication. Although trivalent chromium have been regarded as relatively biologically inert, there are a few salts of chromium III that have been found to be carcinogenic when inhaled, ingested or brought in contact with the tissues. Sensitive persons and industry workers have been subjects of dermatitis, respiratory tract injuries and digestive ulcers due to chromium compounds. In this work, the authors have studied the effect of trivalent and hexavalent chromium compounds on rats measuring the transaminases (GOT and GPT), urea and creatinine levels in serum of chromium poisoned animals at different times.

• Research Organization: Univ. of Valencia, Spain
• OSTI ID: 5573598
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 36:3; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
AMINOTRANSFERASES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
BODY
CARBONIC ACID DERIVATIVES
CHROMIUM COMPOUNDS
CREATININE
DIGESTIVE SYSTEM
ENZYMES
GLANDS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMINES
KIDNEYS
LIVER
MAMMALS
NITROGEN TRANSFERASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RATS
RODENTS
TRANSFERASES
TRANSITION ELEMENT COMPOUNDS
UREA
VERTEBRATES