Effect of the hexapeptide dalargin on ornithine decarboxylase activity in the duodenal mucosa of rats with experimental duodenal ulcer

Journal Article · Sat Aug 01 00:00:00 EDT 1987 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

DOI:https://doi.org/10.1007/BF00840561· OSTI ID:5564056

Yarygin, K N; Shitin, A G; Polonskii, V M; Vinogradov, V A

The authors study the effect of dalargin on ornithine decarboxylase in homogenates of the duodenal ulcer from rats with experimental duodenal ulcer induced by cysteamine. Activity of the enzyme was expressed in pmoles /sup 14/CO/sub 2//mg protein/h. Protein was determined by Lowry's method. The findings indicate that stimulation of ornithine decarboxylase and the antiulcerative effect of dalargin may be due to direct interaction of the peptide with cells of the intestinal mucosa and with enterocytes.

• Research Organization: Institute of Experimental Cardiology, Moscow, USSR
• OSTI ID: 5564056
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 103:3; Other Information: Translated from Byulleten Ehksperimental'noj Biologii i Meditsiny; 103: No. 3, 319-321(Mar 1987)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DECARBOXYLASES
ENZYME ACTIVITY
MUCOUS MEMBRANES
BIOCHEMISTRY
NEUROREGULATORS
BIOLOGICAL EFFECTS
RADIOENZYMATIC ASSAY
RATS
SMALL INTESTINE
ULCERS
CARBON 14 COMPOUNDS
CHEMICAL COMPOSITION
ENKEPHALINS
LABELLING
MOLECULAR STRUCTURE
ORNITHINE
AMINO ACIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARBON-CARBON LYASES
CARBOXY-LYASES
CARBOXYLIC ACIDS
CHEMISTRY
DIGESTIVE SYSTEM
DRUGS
ENDORPHINS
ENZYMES
GASTROINTESTINAL TRACT
INTESTINES
LABELLED COMPOUNDS
LYASES
MAMMALS
MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PEPTIDES
POLYPEPTIDES
PROTEINS
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques