Toxicology of 2,3,7,8 - tetrachlorodibenzo - P - dioxin (TCDD) in aquatic and mammalian species. Part 1. TCDD toxicity, bioaccumulation and biotransformation in fish. Part 2. Effects of TCDD on testicular steroid secretion by the rat

Thesis/Dissertation · Fri Jan 01 04:00:00 EST 1988

OSTI ID:5559251

Kleeman, J M

Experiments were conducted to augment the limited information available on TCDD toxicity, disposition and metabolism in fish. Toxicity was assessed following administration of graded concentrations of TCDD to juvenile rainbow trout, yellow perch, carp, bluegill, large-mouth bass, and bullhead. TCDD-induced mortality was delayed at least one week post-treatment and LD{sub 50} values ranged from 3-16 {mu}g/kg. TCDD-induced morphologic lesions and decreases in body weight were observed and these effects were both species- and dose-dependent. Accumulation, tissue distribution, and depuration of TCDD-derived {sup 3}H were examined in juvenile rainbow trout and yellow perch fed a diet containing {sup 3}H-TCDD. Non-edible fatty tissues were the major depots for TCDD-derived {sup 3}H in both species while skeletal muscle was a minor site of TCDD accumulation. Species differences in TCDD distribution were evident. TCDD produces a dose-related androgenic deficiency in male rats without affecting a change in plasma LH. Decapsulated and isolated perfused testes were used to determine if this androgenic deficiency is due to TCDD-mediated decreases in testicular steroidogenic responsiveness. hCG-Stimulated testosterone secretion and post-perfusion intratesticular testosterone were decreased in TCDD-treated rats indicating a defect in testosterone synthesis.

• Research Organization: Wisconsin Univ., Madison, WI (USA)
• OSTI ID: 5559251
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL ACCUMULATION
BIOLOGICAL VARIABILITY
BIOSYNTHESIS
DIOXIN
DOSE-RESPONSE RELATIONSHIPS
FISHES
GENETIC VARIABILITY
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KETONES
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
RATS
RODENTS
SECRETION
STEROID HORMONES
STEROIDS
SYNTHESIS
TESTOSTERONE
TOXICITY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TROUT
VERTEBRATES