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Information profiles on potential occupational hazards: nitrophenols. Draft report (Second)

Technical Report ·
OSTI ID:5559059
Information profiles are presented for the following nitrophenols: 2-nitrophenol, 3-nitrophenol, 4-nitrophenol, 2,4-dinitrophenol, and 2,4,6-trinitrophenol. The mononitrophenols were moderately toxic to animals, causing initial stimulation and subsequent depression of the respiratory and central nervous systems. Positive results were obtained in several mutagenicity assays for 3-nitrophenol and 4-nitrophenol. 2,4,-Dinitrophenol was far more acutely toxic than other important nitrophenol derivatives. It was able to uncouple oxidative phosphorylation by suppressing the coupling of electron flow to synthesis of adenosine triphosphatase. It caused weakness, intense thirst and sweating, increased body temperature and respiration rate, neuritis, convulsions, and the rapid onset of rigor mortis after death. It has also caused cataracts in humans when used as a weight-reducing aid. Inhalation of 2,4,6-trinitrophenol has caused considerable irritation to the eyes and to the mucous membrane of the respiratory tract. Dermal exposure has produced severe skin irritation and sensitization.
Research Organization:
Syracuse Research Corp., NY (USA). Center for Chemical Hazard Assessment
OSTI ID:
5559059
Report Number(s):
PB-89-215842/XAB; SRC-TR--81-536
Country of Publication:
United States
Language:
English

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Related Subjects

552000 -- Public Health
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AROMATICS
BIOLOGICAL EFFECTS
CHEMICAL ANALYSIS
HYDROXY COMPOUNDS
INDUSTRIAL MEDICINE
MATERIALS
MEDICINE
NITRO COMPOUNDS
NITROPHENOL
OCCUPATIONAL EXPOSURE
OCCUPATIONAL SAFETY
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHENOLS
PRODUCTION
SAFETY
TOXIC MATERIALS
TOXICITY