Genotoxic properties of haloacetonitriles: drinking water by-products of chlorine disinfection
Journal Article
·
· Fundam. Appl. Toxicol.; (United States)
Chlorinated and brominated haloacetonitriles (HAN), known drinking water contaminants which form during chlorine disinfection, were investigated for genotoxic activity. The HAN produced DNA strand breaks in cultured human lymphoblastic (CCRF-CEM) cells, bound to the nucleophilic trapping agent 4-(p-nitrobenzyl)pyridine and formed a covalent bond to polyadenylic acid in a cell-free reaction system. Thus, we have demonstrated that these chemicals are genotoxic, which would indicate a potential for carcinogenic activity and for human health hazard.
- Research Organization:
- Environmental Protection Agency, Cincinnati, OH
- OSTI ID:
- 5558870
- Journal Information:
- Fundam. Appl. Toxicol.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
54 ENVIRONMENTAL SCIENCES
DRINKING WATER
CONTAMINATION
LYMPHOCYTES
STRAND BREAKS
NITRILES
GENETIC EFFECTS
ALKYLATION
BROMINE
CELL CULTURES
CHLORINATION
CHLORINE
COVALENCE
DNA
MUTAGENS
PYRIDINES
TOXICITY
WATER POLLUTION
ANIMAL CELLS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
ELEMENTS
HALOGENATION
HALOGENS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
LEUKOCYTES
MATERIALS
NONMETALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
POLLUTION
SOMATIC CELLS
WATER
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
520200 - Environment
Aquatic- Chemicals Monitoring & Transport- (-1989)
54 ENVIRONMENTAL SCIENCES
DRINKING WATER
CONTAMINATION
LYMPHOCYTES
STRAND BREAKS
NITRILES
GENETIC EFFECTS
ALKYLATION
BROMINE
CELL CULTURES
CHLORINATION
CHLORINE
COVALENCE
DNA
MUTAGENS
PYRIDINES
TOXICITY
WATER POLLUTION
ANIMAL CELLS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
ELEMENTS
HALOGENATION
HALOGENS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
LEUKOCYTES
MATERIALS
NONMETALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
POLLUTION
SOMATIC CELLS
WATER
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
520200 - Environment
Aquatic- Chemicals Monitoring & Transport- (-1989)