Dopaminergic receptor sites in human brain: positron emission tomography

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Neurology; (United States)

DOI:https://doi.org/10.1212/WNL.35.1.16· OSTI ID:5558492

Baron, J C; Comar, D; Zarifian, E; Agid, Y; Crouzel, C; Loo, H; Deniker, P; Kellershohn, C

Positron emission tomography (PET) and /sup 11/C-labeled pimozide were used to study the dopaminergic (DA) receptor sites in the human striatum by comparing the latter with the cerebellum, which lacks DA receptors. Although /sup 11/C-pimozide concentration was not different in these two brain structures up to 53 minutes after IV injection (thus implying large nonspecific binding), a significant retention of radioactivity in striatum relative to cerebellum was found in controls but not in subjects pretreated with the unlabeled competitor haloperidol. This suggests that the striatal retention seen in controls was due to specific binding of /sup 11/C-pimozide to DA receptor sites, whereas prior occupation of the receptor sites by the unlabeled competitor was achieved in pretreated subjects.

• Research Organization: CEA, Orsay, France
• OSTI ID: 5558492
• Journal Information: Neurology; (United States), Vol. 35:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BRAIN
POSITRON COMPUTED TOMOGRAPHY
DOPAMINE
RECEPTORS
CARBON 11
CHEMICAL BONDS
LABELLED COMPOUNDS
MAN
TRACER TECHNIQUES
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PRIMATES
RADIOISOTOPES
SYMPATHOMIMETICS
TOMOGRAPHY
VERTEBRATES
550201* - Biochemistry- Tracer Techniques