Positron emission tomography (PET) studies of dopaminergic/cholinergic interactions in the baboon brain

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Synapse (New York); (USA)

OSTI ID:5893136

Dewey, S L; Brodie, J D; Fowler, J S; MacGregor, R R; Schlyer, D J; King, P T; Alexoff, D L; Volkow, N D; Shiue, C Y; Wolf, A P ^[1]

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1. Brookhaven National Lab., Upton, NY (USA)

Interactions between the dopaminergic D2 receptor system and the muscarinic cholinergic system in the corpus striatum of adult female baboons (Papio anubis) were examined using positron emission tomography (PET) combined with (18F)N-methylspiroperidol (( 18F)NMSP) (to probe D2 receptor availability) and (N-11C-methyl)benztropine (to probe muscarinic cholinergic receptor availability). Pretreatment with benztropine, a long-lasting anticholinergic drug, bilaterally reduced the incorporation of radioactivity in the corpus striatum but did not alter that observed in the cerebellum or the rate of metabolism of (18F)NMSP in plasma. Pretreatment with unlabelled NMSP, a potent dopaminergic antagonist, reduced the incorporation of (N-11C-methyl)benztropine in all brain regions, with the greatest effect being in the corpus striatum greater than cortex greater than thalamus greater than cerebellum, but did not alter the rate of metabolism of the labelled benztropine in the plasma. These reductions in the incorporation of either (18F)NMSP or (N-11C-methyl)benztropine exceeded the normal variation in tracer incorporation in repeated studies in the same animal. This study demonstrates that PET can be used as a tool for investigating interactions between neurochemically different yet functionally linked neurotransmitters systems in vivo and provides insight into the consequences of multiple pharmacologic administration.

• OSTI ID: 5893136
• Journal Information: Synapse (New York); (USA), Journal Name: Synapse (New York); (USA) Vol. 6:4; ISSN 0887-4476; ISSN SYNAE
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ACETYLCHOLINE
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BABOONS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
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BRAIN
CARBON 11
CARBON ISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOPAMINE
DRUGS
EMISSION COMPUTED TOMOGRAPHY
ESTERS
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEMBRANE PROTEINS
METABOLISM
MINUTES LIVING RADIOISOTOPES
MONKEYS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
PHENOLS
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
PROTEINS
QUATERNARY COMPOUNDS
RADIOISOTOPES
RECEPTORS
SPIPERONE
SYMPATHOMIMETICS
TOMOGRAPHY
VERTEBRATES