Effects of. gamma. irradiation on plasma testosterone levels and hepatic drug metabolism in the rat. [Dimethylation of aminopyrine]

Journal Article · Sun Jul 01 00:00:00 EDT 1979 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575033· OSTI ID:5557467

Thithapandha, A; Chanachai, W; Suriyachan, D

When adult male Sprague-Dawley rats were exposed to whole-body irradiation of ..gamma.. rays ranging from 700 to 1000 rad, oxidative demethylation of drugs such as aminopyrine was significantly reduced. In agreement with the report of McTaggart and Wills, we have independently found that this irradiation-induced inhibition of hepatic drug metabolism was a result of blockage of testosterone synthesis or release. The plasma hormone levels in the treated animals (900 rad of ..gamma.. rays) declined gradually from a normal value of 5.5 +- 0.5 ng/ml to a minimum value of 0.9 +- 0.4 ng/ml, which was reached in 4 to 6 days after the irradiaton. It returned to normal level after the 10th day. This hormonal change caused by ..gamma.. irradiation was parallel with the change in aminopyrine demethylation, thus suggesting that impairment of hepatic drug metabolism by ..gamma.. rays was mainly secondary to the effect on the synthesis and/or release of the male sex hormone.

• Research Organization: Mahidol Univ., Bangkok, Thailand
• OSTI ID: 5557467
• Journal Information: Radiat. Res.; (United States), Vol. 19:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANALGESICS
METABOLISM
INHIBITION
TESTOSTERONE
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BLOOD PLASMA
COBALT 60
CORRELATIONS
GAMMA RADIATION
LIVER
RATS
SECRETION
WHOLE-BODY IRRADIATION
ANDROGENS
ANDROSTANES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
COBALT ISOTOPES
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GLANDS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
STEROID HORMONES
STEROIDS
SYNTHESIS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
560114 - Radiation Effects on Biochemicals- In Animals- (-1987)