Results of toxicological testing of Jefferson Paris pilot plant samples

Journal Article · Fri Oct 31 23:00:00 EST 1986 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8669129· OSTI ID:5554929

Miller, R G; Kopfler, F C; Condie, L W; Pereira, M A; Meier, J R; Ringhand, H P; Robinson, M; Casto, B C

Five toxicological tests were performed using concentrated drinking water samples collected at a pilot-scale drinking water treatment plant that had streams treated with different disinfectants (no disinfectant, ozone, chlorine dioxide, monochloramine, or chlorine) before treatment with granular activated carbon (GAC). The toxicological tests used in this study were the Ames Salmonella assay, a subchronic in vivo toxicity assay in mice, the SENCAR mouse skin initiation-promotion assay, a rat liver foci assay, and the lung adenoma assay in strain A mice. These tests were conducted to determine the general toxicity and the mutagenic/carcinogenic potential association with the use of disinfection and/or GAC in the treatment of drinking water. Results indicated that the samples remained mutagenic for the duration of the tests. All the drinking water concentrates (4000 x) prepared by the XAD resin adsorption procedure failed to provide statistically significant indication of carcinogenic activity in the SENCAR mouse, rat liver foci, and the lung adenoma assays. However, concentrates of the chlorine, chlorine dioxide, and monochloramine treated waters gave consistent mutagenic responses in the Ames Salmonella assay. GAC was effective for 6 months in removing both the mutagenicity of chlorine-treated water and the potential of water to become mutagenic when treated with chlorine. A consistent pattern of these differences indicating overt toxicity was not detected.

• Research Organization: Environmental Protection Agency, Cincinnati, OH
• OSTI ID: 5554929
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 69; ISSN EVHPA
• Country of Publication: United States
• Language: English

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560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTIVATED CARBON
ADENOMAS
ADSORBENTS
AMINES
ANIMALS
BACTERIA
BODY
CARBON
CARCINOGEN SCREENING
CARCINOGENESIS
CHALCOGENIDES
CHEMICAL REACTIONS
CHLORAMINES
CHLORINATION
CHLORINE COMPOUNDS
CHLORINE OXIDES
CHROMATOGRAPHY
DIGESTIVE SYSTEM
DISEASES
DRINKING WATER
ELEMENTS
FEDERAL REGION VI
FUNCTIONAL MODELS
GLANDS
HALOGEN COMPOUNDS
HALOGENATION
HYDROGEN COMPOUNDS
ION EXCHANGE CHROMATOGRAPHY
LIVER
LOUISIANA
LUNGS
MAMMALS
MICE
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
NEOPLASMS
NONMETALS
NORTH AMERICA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
OZONE
PATHOGENESIS
PILOT PLANTS
RATS
RESPIRATORY SYSTEM
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
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SEPARATION PROCESSES
SKIN
TOXICITY
USA
VERTEBRATES
WATER
WATER TREATMENT
WATER TREATMENT PLANTS