Synthesis of deuterium-labeled prochlorperazine
Journal Article
·
· J. Pharm. Sci.; (United States)
The propylpiperazine side chain of prochlorperazine was labeled with two, four, or six deuterium atoms by lithium aluminum deuteride reduction of the appropriate amide. The isotopic purity of the products after correcting for chlorine isotopes was greater than 95.7%.
- Research Organization:
- College of Pharmacy, University of Saskatchewan, Saskatoon, Canada
- OSTI ID:
- 5554574
- Journal Information:
- J. Pharm. Sci.; (United States), Journal Name: J. Pharm. Sci.; (United States) Vol. 72:6; ISSN JPMSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL PREPARATION
CHEMICAL REACTIONS
DEUTERIUM COMPOUNDS
DRUGS
HYDROGEN COMPOUNDS
LABELLING
PSYCHOTROPIC DRUGS
REDUCTION
SYNTHESIS
TRANQUILIZERS
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL PREPARATION
CHEMICAL REACTIONS
DEUTERIUM COMPOUNDS
DRUGS
HYDROGEN COMPOUNDS
LABELLING
PSYCHOTROPIC DRUGS
REDUCTION
SYNTHESIS
TRANQUILIZERS