Ethanol enhances de novo synthesis of high density lipoprotein cholesterol

Journal Article · Tue May 01 04:00:00 EDT 1984 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-176-4-RC2· OSTI ID:5551939

Cluette, J E; Mulligan, J J; Noring, R; Doyle, K; Hojnacki, J

Male squirrel monkeys fed ethanol at variable doses were used to assess whether alcohol enhances de novo synthesis of high density lipoprotein (HDL) cholesterol in vivo. Monkeys were divided into three groups: 1) controls fed isocaloric liquid diet; 2) low ethanol monkeys fed liquid diet with vodka substituted isocalorically for carbohydrate at 12% of calories; and 3) High Ethanol animals fed diet plus vodka at 24% of calories. High Ethanol primates had significantly higher levels of HDL nonesterified cholesterol than Control and Low Ethanol animals while serum glutamate oxaloacetate transaminase was similar for the three treatments. There were no significant differences between the groups in HDL cholesteryl ester mass or specific activity following intravenous injection of labeled mevalonolactone. By contrast, High Ethanol monkeys had significantly greater HDL nonesterified cholesterol specific activity with approximately 60% of the radioactivity distributed in the HDL/sub 3/ subfraction. This report provides the first experimental evidence that ethanol at 24% of calories induces elevations in HDL cholesterol in primates through enhanced de novo synthesis without adverse effects on liver function.

• Research Organization: Univ. of Lowell, MA
• OSTI ID: 5551939
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 176:1; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
AMINOTRANSFERASES
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CHOLESTEROL
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ENZYMES
ETHANOL
GLANDS
HYDROXY COMPOUNDS
IN VIVO
LABELLING
LIPIDS
LIPOPROTEINS
LIVER
MAMMALS
MONKEYS
NITROGEN TRANSFERASES
ORGANIC COMPOUNDS
ORGANS
PRECURSOR
PRIMATES
PROTEINS
STEROIDS
STEROLS
SYNTHESIS
TRANSFERASES
VERTEBRATES