Sex and age mortality responses in zinc acetate-treated mice

Journal Article · Wed Jul 01 04:00:00 EDT 1987 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01691804· OSTI ID:5550482

Hogan, G R; Cole, B S; Lovelace, J M

In regard to trace metal treatment or exposure, a number of variables are known to affect the expression of toxicity concerning its time course and degree. For example, known variables are route of administration, anionic component of the test substance, and sex and age of the recipient animal. Concerning the latter, little, if any, data have been reported dealing with sex- and age-related responses to excess zinc in mammalian systems. The primary purpose of the short communication presented here focuses on the determination of median lethal dose in sexually immature, i.e., juvenile, and adult female and male mice following a single zinc acetate insult. In addition, variation of lethality responses was examined with the age and sex groups to a divided treatment of a lethal dosage of zinc acetate, the injections of which were separated by various intervals.

• Research Organization: East Texas State Univ., Commerce
• OSTI ID: 5550482
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 39:1; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
ACETATES
AGE DEPENDENCE
ANIMALS
BLOOD VESSELS
BODY
BODY AREAS
CARBOXYLIC ACID SALTS
CARDIOVASCULAR SYSTEM
DOSES
LETHAL DOSES
MAMMALS
MICE
MORTALITY
NECROSIS
ORGANS
PATHOLOGICAL CHANGES
RODENTS
SEX DEPENDENCE
VASODILATION
VERTEBRATES
ZINC COMPOUNDS