Variation of lead-induced lethality in estradiol-treated mice

Journal Article · Mon Mar 01 04:00:00 EST 1982 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398209530168· OSTI ID:5425703

Hogan, G R

Studies were undertaken to test the female sex hormone ..beta..-estradiol for its ability to modify lethality in young adult female and male mice exposed to lead acetate. Mice were injected with ..beta..-estradiol on day -1 and 0, and immediately after the second injection lead acetate was administered at four subgroup dosages ranging from 75 to 600 mg/kg body weight. Control mice were injected with only lead acetate. On day 4, 6, and 8 after Pb, the median lethal dosages (LD/sub 50/s) were calculated from the observed mortality ratios by a method for moving averages. LD/sub 50/ values were considerably lower for the Pb- and ..beta..-estradiol-injected groups than for the controls. Data from these experiments indicate that the ..beta..-estradiol treatments render both female and male mice more vulnerable to the lethal effects of lead acetate.

• Research Organization: Purdue Univ., Fort Wayne, IN
• OSTI ID: 5425703
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 9:3; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
DOSES
ELEMENTS
ESTRADIOL
ESTRANES
ESTROGENS
HORMONES
HYDROXY COMPOUNDS
INJECTION
INTAKE
LEAD
LETHAL DOSES
MAMMALS
METALS
MICE
MORTALITY
ORGANIC COMPOUNDS
RESPONSE MODIFYING FACTORS
RODENTS
STEROID HORMONES
STEROIDS
SURVIVAL CURVES
TOXICITY
VERTEBRATES