An extensive deletion causing overproduction of yeast iso-2-cytochrome c
Journal Article
·
· Cell; (United States)
CYC7-H3 is a cis-dominant regulatory mutation that causes a 20-fold overproduction of yeast iso-2-cytochrome c. The CYC7-H3 mutation is an approximately 5 kb deletion with one breakpoint located in the 5' noncoding region of the CYC7 gene, approximately 200 base from the ATG initiation codon. The deletion apparently fuses a new regulatory region to the structural portion of the CYC7 locus. The CYC7-H3 deletion encompasses the RAD23 locus, which controls UV sensitivity and the ANP1 locus, which controls osmotic sensitivity. The gene cluster CYC7-RAD23-ANP1 displays striking similarity to the gene cluster CYC1-OSM1-RAD7, which controls, respectively, iso-1-cytochrome c, osmotic sensitivity and UV sensitivity. We suggest that these gene clusters are related by an ancient transpositional event.
- Research Organization:
- Department of Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, New York
- OSTI ID:
- 5547953
- Journal Information:
- Cell; (United States), Journal Name: Cell; (United States) Vol. 25:2; ISSN CELLB
- Country of Publication:
- United States
- Language:
- English
Similar Records
Genetic and biochemical analysis of the CYC7-H3 mutation that causes overproduction of yeast ISO-2-cytochrome C
Deletions, duplications and transpositions of the COR segment that encompasses the structural gene of yeast iso-1-cytochrome c
Deletions of the iso-1-cytochrome c and adjacent genes of yeast: discovery of the OSM1 gene controlling osmotic sensitivity. [Saccharomyces cerevisiae, uv radiation]
Technical Report
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Wed Dec 31 23:00:00 EST 1980
·
OSTI ID:6583835
Deletions, duplications and transpositions of the COR segment that encompasses the structural gene of yeast iso-1-cytochrome c
Conference
·
Mon Dec 31 23:00:00 EST 1979
·
OSTI ID:6774099
Deletions of the iso-1-cytochrome c and adjacent genes of yeast: discovery of the OSM1 gene controlling osmotic sensitivity. [Saccharomyces cerevisiae, uv radiation]
Journal Article
·
Tue Aug 01 00:00:00 EDT 1978
· Genetics; (United States)
·
OSTI ID:6952206
Related Subjects
550400* -- Genetics
560131 -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGY
CHROMOSOMAL ABERRATIONS
CYTOCHROMES
DIFFUSION
DOMINANT MUTATIONS
ELECTROMAGNETIC RADIATION
FUNGI
GENETICS
MICROORGANISMS
MUTATIONS
OSMOSIS
PIGMENTS
PLANTS
RADIATIONS
RADIOSENSITIVITY
ULTRAVIOLET RADIATION
YEASTS
560131 -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGY
CHROMOSOMAL ABERRATIONS
CYTOCHROMES
DIFFUSION
DOMINANT MUTATIONS
ELECTROMAGNETIC RADIATION
FUNGI
GENETICS
MICROORGANISMS
MUTATIONS
OSMOSIS
PIGMENTS
PLANTS
RADIATIONS
RADIOSENSITIVITY
ULTRAVIOLET RADIATION
YEASTS