Thallium-205 NMR determination of the thermodynamic parameters for the binding of monovalent and divalent cations to gramicidin A and C incorporated into model phospholipid membranes: An equilibrium study
Thermodynamic parameters have been determined for the binding of monovalent and divalent cations to gramicidin A and C incorporated in lyso-{alpha}-phosphatidylcholine dispersions. The thermodynamic analyses used equilibrium constants derived from the analysis of Tl-205 NMR chemical shifts using a one-site binding model of the gramicidin channel. Initial experiments determined the thermodynamic parameters of the Tl{sup +} ion binding to gramicidin A. Next, the competitive binding-Tl-205 NMR technique was used to obtain the thermodynamic parameters for the binding of Li{sup +}, Na{sup +}, K{sup +}, Rb{sup +}, Cs{sup +}, NH{sub 4}{sup +} and Ag{sup +} cations to gramicidin A. A similar experiment for the binding of the Li{sup +}, Na{sup +}, K{sup +} and Rb{sup +} cations to gramicidin C was performed. Similar experiments determined the thermodynamic parameter for the Cd{sup ++}, Mg{sup ++}, Ca{sup ++}, Sr{sup ++} and Ba{sup ++} cations. Thermodynamic parameters have also been determined for the binding of the Tl{sup +} ion to gramicidin A incorporated into dimyristoylphosphatidylcholine vesicles using Tl-205 NMR spectroscopy.
- Research Organization:
- Arkansas Univ., Fayetteville, AR (USA)
- OSTI ID:
- 5547692
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ALKALINE EARTH METAL COMPOUNDS
AMMONIUM COMPOUNDS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BARIUM COMPOUNDS
BIOCHEMICAL REACTION KINETICS
CADMIUM COMPOUNDS
CALCIUM COMPOUNDS
CATIONS
CELL CONSTITUENTS
CELL MEMBRANES
CESIUM COMPOUNDS
CHARGED PARTICLES
CHEMICAL SHIFT
DRUGS
EQUILIBRIUM
ESTERS
HEAVY NUCLEI
IONS
ISOTOPES
KINETICS
LIPIDS
LITHIUM COMPOUNDS
MAGNESIUM COMPOUNDS
MATHEMATICAL MODELS
MEMBRANES
NMR SPECTRA
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHOLIPIDS
POTASSIUM COMPOUNDS
REACTION KINETICS
RUBIDIUM COMPOUNDS
SILVER COMPOUNDS
SODIUM COMPOUNDS
SPECTRA
STABLE ISOTOPES
STRONTIUM COMPOUNDS
THALLIUM 205
THALLIUM COMPOUNDS
THALLIUM ISOTOPES
THERMODYNAMICS
TRANSITION ELEMENT COMPOUNDS