Distribution and metabolism of /sup 3/H-labeled leukotriene C/sub 3/ in the mouse
Journal Article
·
· J. Biol. Chem.; (United States)
OSTI ID:5545521
- The Swedish University of Agricultural Sciences, Stockholm
The distribution of (5,6,8,9,11,12-/sup 3/H/sub 6/)leukotriene C/sub 3/ in mice was determined by whole body autoradiography of sagittal sections. Tritium was rapidly eliminated from the circulation by uptake in liver and excretion in bile as well as by renal uptake and excretion in urine. Chromatographic analyses of tritium in tissues and body fluids indicated that leukotrienes C/sub 3/ and D/sub 3/ constituted significant parts of the radioactivity in liver, bile, and small intestine 20 min after intravenous injection, whereas kidney contained leukotriene E/sub 3/ and unidentified metabolites. Lung, pleural fluid, spleen, salivary glands, and connective tissue showed higher concentrations of tritium than blood. The radioactivity in lung consisted predominantly of leukotriene E/sub 3/ with smaller amounts of leukotrienes C/sub 3/ and D/sub 3/.
- OSTI ID:
- 5545521
- Journal Information:
- J. Biol. Chem.; (United States), Journal Name: J. Biol. Chem.; (United States) Vol. 257:1; ISSN JBCHA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Distribution and elimination of (/sup 14/C)-hexachlorobenzene after single oral exposure in cod (Gadus morhua) and flounder (Platichthys flesus)
Endogenous leukotriene D/sub 4/ formation during anaphylactic shock in the guinea pig
Tissue distribution of the tobacco-specific carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and its metabolites in F344 rats
Journal Article
·
Mon Dec 31 23:00:00 EST 1984
· J. Toxicol. Environ. Health; (United States)
·
OSTI ID:5682892
Endogenous leukotriene D/sub 4/ formation during anaphylactic shock in the guinea pig
Journal Article
·
Sat Aug 01 00:00:00 EDT 1987
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:5206264
Tissue distribution of the tobacco-specific carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and its metabolites in F344 rats
Journal Article
·
Mon Jan 31 23:00:00 EST 1983
· Cancer Res.; (United States)
·
OSTI ID:6094736
Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANAPHYLAXIS
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
BILE
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
GASTROINTESTINAL TRACT
GLANDS
INTESTINES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LIVER
LUNGS
MAMMALS
MATERIALS
METABOLISM
MICE
ORGANS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
SALIVARY GLANDS
SMALL INTESTINE
SPLEEN
TISSUE DISTRIBUTION
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANAPHYLAXIS
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
BILE
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
GASTROINTESTINAL TRACT
GLANDS
INTESTINES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LIVER
LUNGS
MAMMALS
MATERIALS
METABOLISM
MICE
ORGANS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
SALIVARY GLANDS
SMALL INTESTINE
SPLEEN
TISSUE DISTRIBUTION
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES