Interactions of ozone and antineoplastic drugs on rat lung fibroblasts and Walker rat carcinoma cells

Journal Article · Sun May 01 00:00:00 EDT 1983 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:5544777

Wenzel, D G; Morgan, D L

Cultured rat lung fibroblasts (F-cells) and Walker rat carcinoma cells (WRC-cells) labeled with /sup 51/Cr were exposed to the following antitumor drugs alone or with O/sub 3/: carmustine (BCNU), doxorubicin (Dox), cisplatin (CPt), mitomycin C (Mit C) or vitamin K/sub 3/ (Vit K). Release of /sup 51/Cr (cell injury) was greater for F-cells than WRC-cells with any single treatment. Pretreatment with any drug (400 microM), except for Vit K with WRC-cells, did not significantly increase O/sub 3/-induced loss of /sup 51/Cr. Co-exposure of F-cells to drugs and O/sub 3/ resulted in a marked potentiation of O/sub 3/-induced injury with Vit K, and an inhibition with Dox.

• Research Organization: Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence
• OSTI ID: 5544777
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Vol. 40:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
DOXORUBICIN
BIOLOGICAL EFFECTS
FIBROBLASTS
LABELLING
MITOMYCIN
OZONE
VITAMIN K
CELL CULTURES
CHROMIUM 51
EXPERIMENTAL NEOPLASMS
LUNGS
RATS
TRACER TECHNIQUES
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AROMATICS
BETA DECAY RADIOISOTOPES
BODY
CHROMIUM ISOTOPES
COAGULANTS
CONNECTIVE TISSUE CELLS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEMATOLOGIC AGENTS
HEPARIN ANTAGONISTS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
QUINONES
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
VERTEBRATES
VITAMINS
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550301 - Cytology- Tracer Techniques