Procollagen-III in serum, plasminogen activation and fibronectin in bronchoalveolar lavage fluid during and following irradiation of human lung

Journal Article · Wed May 01 00:00:00 EDT 1991 · International Journal of Radiation Oncology, Biology and Physics; (USA)

DOI:https://doi.org/10.1016/0360-3016(91)90193-8· OSTI ID:5543747

Maasilta, P; Salonen, E M; Vaheri, A; Kivisaari, L; Holsti, L R; Mattson, K ^[1]

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1. Helsinki Univ. Central Hospital, (Finland)

In the search for predictors of late radiation-induced lung injury we studied procollagen type III peptide concentration (P-III-P) in serum as well as fibronectin and plasminogen activation in bronchoalveolar lavage (BAL) fluid during and following irradiation of human lung. The patients received either high-dose hemithorax irradiation for pleural mesothelioma (11 patients) or high-dose irradiation with individually shaped fields for non-small cell lung cancer (12 patients). The severity of radiation fibrosis was assessed clinically from CT scans 6 months and 12 months after treatment. Four scores were used: severe, moderate, mild, or normal. Radiological lung injury varied from 'severe' (9 patients) to near absence of injury-'normal' (6 patients). Serum levels of P-III-P, when measured weekly during the 5-week period of radiotherapy or at several time-points after treatment, did not show consistent changes, nor did the levels correlate with the score for radiation fibrosis as assessed by CT scanning. Changes in fibronectin levels or in markers of plasminogen activation in BAL fluid did not correlate with the development of late lung injury. The levels of BAL fluid plasmin and plasminogen activator as assessed zymographically, but not the free net enzyme values, showed a tendency to be elevated in patients with severe radiation-induced lung injury, suggesting a possible role for inhibitors of the plasminogen activation cascade in the process of radiation-induced lung injury.

• OSTI ID: 5543747
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (USA), Vol. 20:5; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GLUCOPROTEINS
BIOSYNTHESIS
LUNGS
BIOLOGICAL RADIATION EFFECTS
PEPTIDES
PLASMINOGEN
RADIOTHERAPY
SIDE EFFECTS
BIOLOGICAL MARKERS
ENZYME INHIBITORS
LAVAGE
MAN
PATIENTS
ANIMALS
BIOLOGICAL EFFECTS
BLOOD COAGULATION FACTORS
BODY
CARBOHYDRATES
COAGULANTS
DRUGS
FIBRINOLYTIC AGENTS
GLYCOPROTEINS
HEMATOLOGIC AGENTS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RADIATION EFFECTS
RADIOLOGY
RESPIRATORY SYSTEM
SACCHARIDES
SYNTHESIS
THERAPY
VERTEBRATES
560151* - Radiation Effects on Animals- Man