Determination of catecholamines and their 3-O-methylated metabolites in urine by mass fragmentography with use of deuterated internal standards
Journal Article
·
· Clin. Chem. (Winston-Salem, N.C.); (United States)
OSTI ID:5531222
We report the determination of catecholamines (dopamine, norepinephrine, and epinephrine) and their 3-O-methylated metabolites (3-methoxytyramine, normetanephrine, and metanephrine) in urine by gas chromatography/mass spectrometry, with use of stable isotopically labeled internal standards. Normal excretion values in terms of creatinine, expressed as a function of age, are given, together with results obtained for patients with neuroblastoma, ganglioneuroblastoma, pheochromocytoma, parkinsonism treated with L-DOPA plus peripheral decarboxylase inhibitor, and a patient with cardiogenic shock treated with dopamine. The results obtained for normal adults are discussed in relation to other catecholamine metabolites and mean overall catecholamine turnover.
- OSTI ID:
- 5531222
- Journal Information:
- Clin. Chem. (Winston-Salem, N.C.); (United States), Journal Name: Clin. Chem. (Winston-Salem, N.C.); (United States) Vol. 25:3; ISSN CLCHA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102* -- Chemical & Spectral Procedures
550201 -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
AROMATICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CALIBRATION STANDARDS
CATECHOLAMINES
CHROMATOGRAPHY
DEUTERIUM COMPOUNDS
DISEASES
GAS CHROMATOGRAPHY
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
MASS SPECTROSCOPY
MATERIALS
METABOLITES
NEOPLASMS
ORGANIC COMPOUNDS
PATIENTS
PHENOLS
POLYPHENOLS
SEPARATION PROCESSES
SPECTROSCOPY
STANDARDS
URINE
WASTES
400102* -- Chemical & Spectral Procedures
550201 -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
AROMATICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CALIBRATION STANDARDS
CATECHOLAMINES
CHROMATOGRAPHY
DEUTERIUM COMPOUNDS
DISEASES
GAS CHROMATOGRAPHY
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
MASS SPECTROSCOPY
MATERIALS
METABOLITES
NEOPLASMS
ORGANIC COMPOUNDS
PATIENTS
PHENOLS
POLYPHENOLS
SEPARATION PROCESSES
SPECTROSCOPY
STANDARDS
URINE
WASTES