Induction of diphtheria toxin-resistant mutants in human cells by ultraviolet light

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/2.12.1289· OSTI ID:5529130

Rocchi, P; Ferreri, A M; Capucci, A; Prodi, G ^[1]

---

1. Bologna Univ. (Italy)

Stable spontaneous mutants resistant to the protein synthesis inhibitor diphtheria toxin (DT) have been selected in human cell line EUE at a very low frequency (< 8 x 10/sup -6/). U.v.-induced mutation has been quantitatively measured: treatment of cells with u.v. light increased the frequencies of diphtheria toxin resistant (DTsup(r)) mutants up to 1000-fold. The maximum recovery of DTsup(r) mutants was observed after a short expression period, for all u.v. doses tested, and was followed by a decrease in mutation frequency on subsequent passages.

• OSTI ID: 5529130
• Journal Information: Carcinogenesis (N.Y.); (United States), Vol. 2:12
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DIPHTHERIA
DISEASE RESISTANCE
NEAR ULTRAVIOLET RADIATION
RADIOINDUCTION
MUTANTS
CELL CULTURES
EPITHELIUM
MAN
MUTATION FREQUENCY
SURVIVAL CURVES
TOXINS
ANIMAL TISSUES
ANIMALS
ANTIGENS
BACTERIAL DISEASES
BODY
DISEASES
ELECTROMAGNETIC RADIATION
INFECTIOUS DISEASES
MAMMALS
MATERIALS
PRIMATES
RADIATIONS
TISSUES
TOXIC MATERIALS
ULTRAVIOLET RADIATION
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)