Induction of diphtheria toxin-resistant mutants in human cells by ultraviolet light

Journal Article · Thu Jan 01 04:00:00 EST 1981 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/2.12.1289· OSTI ID:5463567

Rocchi, P; Ferreri, A M; Capucci, A; Prodi, G

Stable spontaneous mutants resistant to the protein synthesis inhibitor diphtheria toxin (DT) have been selected in human cell line EUE at a very low frequency (less than 8 x 10(-6)). U.v.-induced mutation has been quantitatively measured: treatment of cells with u.v. light increased the frequencies of diphtheria toxin resistant (DTr) mutants up to 1000-fold. The maximum recovery of DTr mutants was observed after a short expression period, for all u.v. doses tested, and was followed by a decrease in mutation frequency on subsequent passages.

• Research Organization: Istituto di Cancerologia, Universita di Bologna, Italy
• OSTI ID: 5463567
• Journal Information: Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 2:12; ISSN CRNGD
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DIPHTHERIA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
INFECTIOUS DISEASES
MAMMALS
MAN
MATERIALS
MUTATION FREQUENCY
MUTATIONS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
SPONTANEOUS MUTATIONS
TOXIC MATERIALS
TOXINS
ULTRAVIOLET RADIATION
VERTEBRATES