Induction of diphtheria toxin-resistant mutants in human cells by ultraviolet light

Journal Article · Thu Jan 01 04:00:00 EST 1981 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/2.12.1289· OSTI ID:5529130

Rocchi, P; Ferreri, A M; Capucci, A; Prodi, G ^[1]

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1. Bologna Univ. (Italy)

Stable spontaneous mutants resistant to the protein synthesis inhibitor diphtheria toxin (DT) have been selected in human cell line EUE at a very low frequency (< 8 x 10/sup -6/). U.v.-induced mutation has been quantitatively measured: treatment of cells with u.v. light increased the frequencies of diphtheria toxin resistant (DTsup(r)) mutants up to 1000-fold. The maximum recovery of DTsup(r) mutants was observed after a short expression period, for all u.v. doses tested, and was followed by a decrease in mutation frequency on subsequent passages.

• OSTI ID: 5529130
• Journal Information: Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 2:12; ISSN CRNGD
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
ANTIGENS
BACTERIAL DISEASES
BODY
CELL CULTURES
DIPHTHERIA
DISEASE RESISTANCE
DISEASES
ELECTROMAGNETIC RADIATION
EPITHELIUM
INFECTIOUS DISEASES
MAMMALS
MAN
MATERIALS
MUTANTS
MUTATION FREQUENCY
NEAR ULTRAVIOLET RADIATION
PRIMATES
RADIATIONS
RADIOINDUCTION
SURVIVAL CURVES
TISSUES
TOXIC MATERIALS
TOXINS
ULTRAVIOLET RADIATION
VERTEBRATES