Effect of chlorphentermine on incorporation of (/sup 14/C)choline in the rat lung phospholipids
The effect of chlorphentermine (CP) treatment (50 mg/kg/day, per os (po)) on the incorporation of (/sup 14/C)choline into rat lung phospholipid was studied. Total phospholipid content was increased 2.0-fold and 1.7-fold after seven and /sup 14/ days, respectively, compared with the pair-fed rats. The incorporation of (14C)choline into phosphatidylcholine (PC) was significantly inhibited by either seven or 14 days of CP treatment. Nevertheless, the PC content was significantly increased by day 7 and stayed elevated at day 14 of CP treatment. Choline and phosphorylcholine contents were significantly decreased by the CP treatment. These results suggest that the higher accumulation of PC is due to inhibition of enzymes involved in the hydrolysis of phospholipids rather than to a stimulation of the phospholipid synthesis.
- Research Organization:
- Univ. of Mississippi Medical Center, Jackson
- OSTI ID:
- 5528528
- Journal Information:
- Lipids; (United States), Journal Name: Lipids; (United States) Vol. 3; ISSN LPDSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
CARBON 14 COMPOUNDS
CHEMICAL REACTIONS
CHOLINE
DECOMPOSITION
DRUGS
ESTERS
HYDROLYSIS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LIPIDS
LIPOTROPIC FACTORS
LUNGS
LYSIS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
QUATERNARY COMPOUNDS
RATS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
SOLVOLYSIS
TRACER TECHNIQUES
VERTEBRATES