Polysaccharides induce radioprotection of murine hemopoietic stem cells and increase the LD50/30 days

Journal Article · Sat Feb 01 00:00:00 EST 1986 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576553· OSTI ID:5528249

Maisin, J R; Kondi-Tamba, A; Mattelin, G

Intravenous administration of 60 mg/kg of a polysaccharide (MNR, MNZ, GLP/BO4, GLP/BO5) significantly decreases the mortality of mice exposed to a single dose of X rays. The dose reduction factors (DRF) obtained for MNZ, MNR, GLP/BO4, and GLP/BO5 given intraperitoneally 15 min before exposure were 2.16, 1.93, 1.80, and 1.94, respectively. The DRF was not increased when MNZ or GLP/BO4 were combined with injection of AET before X-ray exposure. The LD50 for the CFUs exposed in vivo in mice was 1.13 Gy for the treated mice and 0.75 Gy for the nontreated mice. This corresponds to a DRF of 1.6. The DRF calculated from the slope is 1.27.

• Research Organization: Radiobiology Department, C.E.N./S.C.K., Mol, Belgium
• OSTI ID: 5528249
• Journal Information: Radiat. Res.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
POLYSACCHARIDES
RADIOSENSITIVITY EFFECTS
DOSE-RESPONSE RELATIONSHIPS
MICE
MORTALITY
RADIATION PROTECTION
RADIOSENSITIVITY
STEM CELLS
SURVIVAL TIME
X RADIATION
ANIMAL CELLS
ANIMALS
CARBOHYDRATES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
RADIATIONS
RODENTS
SACCHARIDES
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals