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Lymphatic flow in humans as indicated by the clearance of /sup 125/I-labeled albumin from the subcutaneous tissue of the leg

Journal Article · · J. Surg. Res.; (United States)
; ; ;

Since the removal of albumin from the extracellular space and its return to the vascular compartment is the essential function of the lymphatic system, the rate at which it is removed from the interstitial tissue may be regarded as a means of estimating lymphatic efficiency. An objective measure of lymphatic function can be obtained by monitoring the rate of clearance following injection of /sup 125/I-labeled albumin (RIHSA) from the subcutaneous tissue of a limb. The clearance of /sup 125/I-RIHSA from lower limb was monitored in a group of patients with normal limbs, patients with unilateral edema due to deep vein thrombosis, and patients with bilateral edema due to hypoproteinemia. The mean T1/2 in normal legs was 32.7 hr, compared to 23.7 hr in edematous limbs due to deep vein thrombosis and 19.4 in edematous limbs due to hypoproteinemia. There is a clear-cut difference in clearance rate between edematous and nonedematous limbs. This suggests that lymphatic flow is increased in edema due to venous obstruction and hypoproteinemia.

Research Organization:
Department of Surgery, Columbus Hospital, Chicago, Illinois
OSTI ID:
5527752
Journal Information:
J. Surg. Res.; (United States), Journal Name: J. Surg. Res.; (United States) Vol. 35:2; ISSN JSGRA
Country of Publication:
United States
Language:
English

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Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
BETA DECAY RADIOISOTOPES
BLOOD-PLASMA CLEARANCE
BODY
CARDIOVASCULAR DISEASES
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISEASES
DYNAMIC FUNCTION STUDIES
EDEMA
ELECTRON CAPTURE RADIOISOTOPES
FEMALES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LYMPHATIC SYSTEM
MALES
NUCLEI
NUTRITIONAL DEFICIENCY
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PROTEINS
RADIOISOTOPES
SKIN
SYMPTOMS
THROMBOSIS
TRACER TECHNIQUES
VASCULAR DISEASES