Effect of dietary fat levels on the susceptibility of colonic cells to nuclear-damaging agents
Journal Article
·
· Nutr. Cancer; (United States)
The effect of two levels and types of dietary fats on the susceptibility of colonic cells to the nuclear-damaging effect of 1,2-dimethylhydrazine dihydrochloride (DMH), 2-amino-3,4-dimethylimidazo(4,5-f)quinoline (MeIQ), and gamma-radiation was investigated. Corn oil and beef tallow were added to the semisynthetic diet at 5% and 20% levels (weight/weight). A diet-related effect was not evident until after two weeks of feeding. Animals (C57BL/6J female mice) that were given the 20% corn oil or beef tallow diets had significantly (p less than 0.05) more nuclear aberrations in their colons 24 hours following treatment with DMH (5 mg or 10 mg/kg body wt or MeIQ (100 mg/kg body weight) than did those given low-fat diets (5% corn oil or beef tallow). The nuclear-damaging effect of gamma radiation was unaffected by dietary treatments. A high-fat diet had the most pronounced effect on DMH-treated animals, and maximum nuclear aberrations were observed 24 hours following the treatment. Thus, we concluded that increased levels of dietary fats elevate the toxicity of DMH and MeIQ to colonic epithelial cells.
- Research Organization:
- Ludwig Institute for Cancer Research, Toronto, Ontario, Canada
- OSTI ID:
- 5525168
- Journal Information:
- Nutr. Cancer; (United States), Journal Name: Nutr. Cancer; (United States) Vol. 2; ISSN NUCAD
- Country of Publication:
- United States
- Language:
- English
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Effects of 2-acetylaminofluorene, dietary fats and antioxidants on nuclear envelope cytochrome P-450
Journal Article
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Sat Dec 31 23:00:00 EST 1983
· Nutr. Cancer; (United States)
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OSTI ID:5090703
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Journal Article
·
Mon Feb 28 23:00:00 EST 1983
· J. Nutr.; (United States)
·
OSTI ID:5602879
Effects of 2-acetylaminofluorene, dietary fats and antioxidants on nuclear envelope cytochrome P-450
Conference
·
Thu May 01 00:00:00 EDT 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:7145089
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AROMATICS
AZAARENES
AZINES
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CELL NUCLEI
DIET
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
EPITHELIUM
FATS
GAMMA RADIATION
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HYDRAZINE
INTESTINES
IONIZING RADIATIONS
LARGE INTESTINE
MAMMALS
MICE
NITROGEN COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
QUINOLINES
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SENSITIVITY
TISSUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AROMATICS
AZAARENES
AZINES
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CELL NUCLEI
DIET
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
EPITHELIUM
FATS
GAMMA RADIATION
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HYDRAZINE
INTESTINES
IONIZING RADIATIONS
LARGE INTESTINE
MAMMALS
MICE
NITROGEN COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
QUINOLINES
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SENSITIVITY
TISSUES
VERTEBRATES