Inhomogeneity of the nucleus to /sup 125/IUdR cytotoxicity
Journal Article
·
· Radiat. Res.; (United States)
Synchronized suspension cultures of Chinese hamster ovary (CHO) cells were used to determine the lethal effects produced by the decay of /sup 125/I incorporated into different subfractions of the nuclear genome. Such a shift in nuclear incorporation pattern was achieved by using the drug aphidicolin, which inhibits 95% of all nuclear DNA synthesis, is nontoxic to cells in a colony-forming assay, and does not modify the radiation response of CHO cells to X irradiation. These data in combination with survival curves of CHO cells labeled with /sup 125/I-iododeoxyuridine (/sup 125/IUdR) either with or without aphidicolin showed a dramatic change in the survival response (D/sub 0/: 30 decays/cell and 96 decays/cell, respectively). It is concluded, therefore, that the nucleus is not a homogeneous target for radiation-induced cell death because when subfractions of the nuclear genome are labeled, radically different levels in cell survival are obtained.
- Research Organization:
- Univ. of Utah Medical Center, Salt Lake City
- OSTI ID:
- 5520506
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 102:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Radiation lethality and the cellular genome
Low-LET radiotoxicity from incorporated {sup 3}H or {sup 125}I during the cell cycle: Implications for mechanisms of high-LET damage
Target for radiation-induced division delay
Thesis/Dissertation
·
Sat Dec 31 23:00:00 EST 1983
·
OSTI ID:5808109
Low-LET radiotoxicity from incorporated {sup 3}H or {sup 125}I during the cell cycle: Implications for mechanisms of high-LET damage
Conference
·
Sat Dec 30 23:00:00 EST 1995
·
OSTI ID:400733
Target for radiation-induced division delay
Journal Article
·
Sun Nov 30 23:00:00 EST 1980
· Radiat. Res.; (United States)
·
OSTI ID:6984334
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560122 -- Radiation Effects on Cells-- Internal Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIMETABOLITES
AUTORADIOGRAPHY
AZINES
BETA DECAY RADIOISOTOPES
CELL CONSTITUENTS
CELL CULTURES
CELL KILLING
CELL NUCLEI
CHO CELLS
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
IODODEOXYURIDINE
IODOURACILS
IONIZING RADIATIONS
ISOTOPES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATION DOSE DISTRIBUTIONS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RIBOSIDES
SPATIAL DOSE DISTRIBUTIONS
SURVIVAL CURVES
SYNCHRONOUS CULTURES
URACILS
X RADIATION
560122 -- Radiation Effects on Cells-- Internal Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIMETABOLITES
AUTORADIOGRAPHY
AZINES
BETA DECAY RADIOISOTOPES
CELL CONSTITUENTS
CELL CULTURES
CELL KILLING
CELL NUCLEI
CHO CELLS
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
IODODEOXYURIDINE
IODOURACILS
IONIZING RADIATIONS
ISOTOPES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATION DOSE DISTRIBUTIONS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RIBOSIDES
SPATIAL DOSE DISTRIBUTIONS
SURVIVAL CURVES
SYNCHRONOUS CULTURES
URACILS
X RADIATION