Genotoxicity induced by a shale oil byproduct in Chinese hamster cells following metabolic activation
Conference
·
OSTI ID:5519629
A process water obtained from a holding tank during the surface retorting of oil shale has been shown to induce a linear dose response of 100 histidine revertants/sub ..mu../1 in the Ames/Salmonella test. The complex mixture has also previously been shown to induce genotoxicity in mammalian cells following activation by near ultraviolet light and natural sunlight. This report focuses on the effects of a particular oil shale retort process water on cultured Chinese hamster cells following metabolic activation by either rat liver homogenate or lethally irradiated but metabolically competent Syrian hamster embryonic cells. Cytotoxic and mutagenic responses induced by the process water and a fractionated sample from it containing the majority of the mutagenic activity (as assessed by the Salmonella test) were measured under conditions designed to optimally measure the mutagenic potency of the promutagen, benzo(a)pyrene. These results suggest a possible discrepancy in the genotoxic potential of this complex mixture when various methods are utilized to measure its potential.
- Research Organization:
- Los Alamos National Lab., NM (USA)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 5519629
- Report Number(s):
- LA-UR-82-271; CONF-820122-1; ON: DE82010427
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
04 OIL SHALES AND TAR SANDS
040700* -- Oil Shales & Tar Sands-- Health & Safety
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560302 -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BACTERIA
BENZOPYRENE
CELL CULTURES
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DATA
DISPERSIONS
ENERGY SOURCES
EXPERIMENTAL DATA
FOSSIL FUELS
FUELS
HAMSTERS
HYDROCARBONS
INFORMATION
MAMMALS
METABOLIC ACTIVATION
MICROORGANISMS
MINERAL OILS
MIXTURES
MUTAGEN SCREENING
MUTAGENESIS
MUTANTS
NUMERICAL DATA
OILS
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
PARAHO PROCESS
PROCESS SOLUTIONS
REVERTANTS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SHALE OIL
SOLUTIONS
TOXICITY
VERTEBRATES
040700* -- Oil Shales & Tar Sands-- Health & Safety
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560302 -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BACTERIA
BENZOPYRENE
CELL CULTURES
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DATA
DISPERSIONS
ENERGY SOURCES
EXPERIMENTAL DATA
FOSSIL FUELS
FUELS
HAMSTERS
HYDROCARBONS
INFORMATION
MAMMALS
METABOLIC ACTIVATION
MICROORGANISMS
MINERAL OILS
MIXTURES
MUTAGEN SCREENING
MUTAGENESIS
MUTANTS
NUMERICAL DATA
OILS
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
PARAHO PROCESS
PROCESS SOLUTIONS
REVERTANTS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SHALE OIL
SOLUTIONS
TOXICITY
VERTEBRATES