Rapid repression of quiescence-specific gene expression by epidermal growth factor, insulin, and PP60/sup V-SRC/

Journal Article · Wed Mar 01 00:00:00 EST 1989 · Molecular and Cellular Biology; (USA)

DOI:https://doi.org/10.1128/MCB.9.3.1371· OSTI ID:5518374

Bedard, P A ^[1]; Yannoni, Y; Simmons, D L; Erikson, R L ^[2]

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1. Montreal Univ., PQ (Canada)
2. Harvard Univ., Cambridge, MA (USA). Dept. of Biology

The authors isolated a cDNA for p20K, a secreted protein preferentially synthesized in nonproliferating cells, p20K mRNA and protein levels declined rapidly following treatment with various mitogens. DNA sequence analysis of the p20K cDNA predicted a novel protein distantly related to {alpha}/sub 2{mu}/-globulin and plasma retinol-binding.

• OSTI ID: 5518374
• Journal Information: Molecular and Cellular Biology; (USA), Vol. 9:3; ISSN 0270-7306
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GROWTH FACTORS
GENES
MITOGENS
BIOLOGICAL EFFECTS
DNA SEQUENCING
GENE REPRESSORS
GENETIC MAPPING
GLOBULINS
INSULIN
MESSENGER-RNA
HORMONES
MAPPING
NUCLEIC ACIDS
NUCLEOPROTEINS
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PROTEINS
RNA
STRUCTURAL CHEMICAL ANALYSIS
550200* - Biochemistry
550400 - Genetics