Cadmium, zinc and copper in horse kidney metallothionein

Journal Article · Sat Dec 01 04:00:00 EST 1979 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(79)90010-0· OSTI ID:5518341

Nordberg, M; Elinder, C G; Rahnster, B

Cadium, zinc, and copper were determined in kidney cortex samples and in protein fractions obtained from 20 normal Swedish horses. Cadmium concentrations in kidneys ranged from 0.01 to 1.46 mmole/kg. Zinc concentrations in kidneys increased with increasing cadmium concentrations. At low concentrations of cadmium the increase of zinc was almost equimolar with the increase in cadmium, but at higher concentrations of cadmium the increase of zinc was less pronounced. Copper concentrations ranged from 0.07 to 0.22 mmole Cu/kg and were not related to the cadmium concentration. The increase of zinc in kidney cortex took place in the metallothionein (MT) fractions where also almost all cadmium was recovered. The molar ratio of zinc and cadmium in MT was close to one at low concentrations (below 0.1 mmole/kg) of cadmium but the ratio decreased with increasing cadmium concentrations in the kidney. This change in molar ratio of zinc and cadmium in MT explains the leveling off in zinc increase at cadmium concentrations in kidney exceeding 0.6 mmole/kg.

• Research Organization: Karolinska Inst. and National Swedish Environmental Protection Board, Stockholm
• OSTI ID: 5518341
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 20:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BODY
CADMIUM
COPPER
DATA
DATA FORMS
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EXPERIMENTAL DATA
HORSES
INFORMATION
ISOLATED VALUES
KIDNEYS
KINETICS
MAMMALS
METABOLISM
METALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PROTEINS
QUANTITY RATIO
REACTION KINETICS
RESPONSE MODIFYING FACTORS
TISSUE DISTRIBUTION
TRANSITION ELEMENTS
VERTEBRATES
ZINC